He also expressed hope that Russia would win in Syria and help restore the Syrian army that would over time defeat the Islamic State (ISIL) terrorist group.
"I believe that the Cold War never ended," Stone told El Mundo.
Stone said that the 1990s were lucky times for Washington as it had to do with Boris Eltsin, "the friendliest Russian president one can ever imagine."
Eltsin was the president who paved the way to Russia for "predatory capitalism", he said.
"That was the end of Russia, and at the time the West was very glad and friendly," Stone said.
"There is the law of nature – if your enemy is forced to be careful. The enemy will strike back at you. This is what happened to Russia. We turned it into a country which has reasons to beware of the US," the director said.
Commenting on the Russian military operation in Syria, he said: "It is a good thing that Russia has started taking action in Syria. I hope he wins and helps restore the Syrian army which would defeat ISIL."
Stone added that ISIL emerged as a result of the Iraq War.
"We created the chaos we are now witnessing in the Middle East. We destabilized the entire region, but now we are blaming ISIL for that. But we are to blame, we are now an empire of chaos," the director said.
Stone underscored that with its military operation in Syria, Russia is protecting its old-time ally in the region. Meanwhile, Washington continues to insist on regime change in Syria, making a "new Hitler" of President Bashar al-Assad.
"Assad is a tough guy. And I know he is to blame for many atrocities against his own people. But he is not better and not worse than tyrants from Saudi Arabia, or Saddam Hussein – at the time when he was our ally and before," he said.