"I was not encouraged by the vote that took place this morning in the Netherlands," Lagarde said at an annual Women in the World summit in New York City.
On Wednesday, 61.1 percent of Dutch voters rejected the EU-Ukraine association deal’s ratification in the advisory referendum, according to preliminary results ahead of their April 12 publication.
The EU-Ukraine Association Agreement establishes a political and economic association between Kiev and Brussels. The Netherlands is the last EU country to ratify the 2014 deal to this effect. The agreement’s free trade economic zone took effect on January 1 this year.
Lagarde said another risk "on the horizon" was the June 23 referendum for the United Kingdom to stay or leave the European Union.
"The risk of Brexit is a worry. It's a worry because it's uncertainty, it's apprehension, the outcome of any new regime is totally unknown, and it's a worry. London is a big financial city, has huge links around Europe and around the world, and it's one of the risks that we have on the horizon as well," she stressed.
Opinion polls gave a 1-percent edge to Vote Remain supporters this week as a nationwide scandal broke out over the British government’s $13-million plan to distribute leaflets promoting a pro-EU campaign.