According to the poll, southern parts of the country, where the poorest regions are located, are likely to vote 'No,' by an 11-point margin. Overall, Italians are likely to vote "No" by a seven-point margin. By way of comparison, the UK ‘Leave' campaign won the Brexit referendum with a 4-percent margin.
According to Luca Comodo, director at the polling company Ipsos, most voters believe that rejecting Mr Renzi's plans is a vote for change, according to Express.co.uk.
"The south is where protest and rage are amplified," said Mr. Comodo.
Most Italians are not likely to base their vote on a thorough analysis of proposed constitutional changes, but rather on their own confidence, or lack thereof, in Prime Minister Renzi, political researchers say. Many Italians tend to believe it is Renzi's government that is responsible for the country's current troubled economy.
"Many people are voting No because they are against Renzi, without even knowing what this entails," said Martina Riccio, a 32-year-old market researcher.
"We should send this government packing and let everyone know how much they've screwed us," Express.co.uk cites one Italian saying.