"Dr. Ben Carson is a disconcerting and disturbingly unqualified choice to lead a department as complex and consequential as Housing and Urban Development," Pelosi stated.
The release also noted that Carson lacks the credentials to head an agency whose policies affects families across the United States.
"Our country deserves a HUD Secretary with the relevant experience to protect the rights of homeowners and renters, particularly in low-income and minority communities, and to ensure that everyone in our country can have access to safe and affordable housing without facing discrimination or homelessness," Pelosi added.
Earlier Monday, Trump announced Carson as his nominee for HUD secretary, pending a confirmation vote by the US Senate.
Carson ran against Trump for the 2016 Republican presidential nomination but endorsed the eventual nominee shortly after suspending his own campaign.