"All military action must halt. All remaining civilians must be allowed safe conduct out from Eastern Aleppo. Priority must be placed on saving lives. Civilians should not be hostage to negotiations," Grandi said in a statement.
According to Grandi, humanitarian organizations should be provided with free access to all areas in Syria.
"UNHCR and partners have provided trauma help to more than 8,000 children in recent days… For the sake of civilian protection everywhere, Syria’s conflict must be ended, now, and without delay," Grandi added.
On Friday, the Russian Defense Ministry announced that Aleppo was now under full government control with the Syrian army operation to retake the eastern districts completed. Civilians and militants were leaving the city amid a ceasefire agreement between the remaining pockets of resistance and government forces.