Engage Cuba has estimated that completely dismantling Obama's historic rapprochement with Cuba would cost the US economy $6.6 billion and 12,295 jobs over the course of Trump's first term in office alone.
"If President Trump rolled back our Cuba policy, he would add job-killing government regulations on US businesses." James Williams, president of Engage Cuba, said in the report, released on Thursday.
"This directly conflicts with President Trump's campaign promises of removing onerous regulations and red tape on US businesses."
Williams pointed out that rapprochement with Cuba has largely benefited American companies, created thousands of new jobs and has boosted Cuba's progressing private sector.
Since Obama announced a new era in US-Cuba relations, direct flights to the island have resumed, and several major US companies, such as AirBnb, TripAdvisor and a number of telecommunications providers, have taken advantage of the opportunity.
According to the report, the airline sector alone would lose about $2 billion in revenue over the next four years, were Trump to reverse Cuba policies. But manufacturing, tourism, farming and shipping industries would also be hurt.