Sputnik: Do you believe that Lee Harvey Oswald alone was behind the assassination of President John F. Kennedy?
John C. McAdams: There's extraordinarily strong evidence that he shot Kennedy and an absence of evidence that anyone else, in fact, was involved. He was trying to get into Cuba because he was a huge fan of the Castro revolution and believed himself to be a Marxist.
He had gone to the Soviet Union and was very disillusioned with communism there. Like a lot of people who were disillusioned with communism in Russia, he looked for a new communist exemplar regime and he thought Castro's regime might be it and he wanted to get into Cuba, but failed to do so.

Sputnik: Do you believe that the CIA or the Castro Regime were involved in the assassination?
John C. McAdams: The CIA is, after all, a secret organization that certainly was willing during the heyday of the Cold War to mount assassination plots, particularly against Fidel Castro. So when you ask who might be able to kill Kennedy, or who might want to kill Kennedy — the CIA pretty much pops up as a likely candidate.

That is to say that he knew about the hostility between the Kennedy administration and Castro's regime and saw himself as protecting the Cuban Revolution.