Early estimates reported at least 116 passengers had been taken to the hospital with injuries, some serious.
A statement released by Amtrak noted that the organization is cooperating with a National Transportation Safety Board (NTSB) investigation into the fatal crash.
The passenger rail company released a statement noting that it is ‘deeply saddened' by the deaths of its employees, according to the Associated Press.
CSX did not immediately return email and telephone inquiries following the tragedy. Police report that the CSX freight was unoccupied at the time of the high-speed crash.
An initial statement by South Carolina Governor Henry McMaster claimed that "it appears the Amtrak was on the wrong track" and the unattended CSX train "was on the track it was supposed to be on," leading to suspicions that the Amtrak train was incorrectly switched by the freight carrier.
US freight rail corporations have resisted implementing Positive Train Control (PTC) on their networks, citing high costs, while politicians and industry insiders note the life-saving utility of the globally-accepted rail technology.