"A shooting incident at approximately 4:30 a.m. today has left two 319th Reconnaissance Wing active duty military members dead", the release said.
The incident is contained and there is no ongoing risk to other personnel at the base at this time, the incident also said.
The incident is currently under investigation, the release added.
On 21 May, the shooting erupted near the base's North Gate early morning local time. However, the shooter at the US Naval Air Station (NAS) Corpus Cristi in the state of Texas has been quickly "neutralised", according to the Navy's statement.
On 6 December 2019, a Saudi pilot trainee opened fire at the US Naval Air Station Pensacola, killing three US sailors and wounding eight others before the authorities shot him dead.
Shortly after the incident, the United States terminated all operational training for Saudi servicemen for an indefinite period.