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Israel to the Rescue? New Drug Developed in Tel Aviv Hospital May Help Battle Severe COVID-19 Cases

© CDCThis illustration, created at the Centers for Disease Control and Prevention (CDC), reveals ultrastructural morphology exhibited by coronaviruses. Note the spikes that adorn the outer surface of the virus, which impart the look of a corona surrounding the virion, when viewed electron microscopically. A novel coronavirus, named Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), was identified as the cause of an outbreak of respiratory illness first detected in Wuhan, China in 2019. The illness caused by this virus has been named coronavirus disease 2019 (COVID-19).
This illustration, created at the Centers for Disease Control and Prevention (CDC), reveals ultrastructural morphology exhibited by coronaviruses. Note the spikes that adorn the outer surface of the virus, which impart the look of a corona surrounding the virion, when viewed electron microscopically. A novel coronavirus, named Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), was identified as the cause of an outbreak of respiratory illness first detected in Wuhan, China in 2019. The illness caused by this virus has been named coronavirus disease 2019 (COVID-19). - Sputnik International, 1920, 22.02.2021
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Having vaccinated more than four million of its nine million citizens, Israel is now set to become the first nation to find a cure for the virus that has killed over 5,000 people across the nation.

Tel Aviv's Ichilov hospital has developed a drug that is already being touted as a miracle that fights the cytokine storm, a potentially lethal immune overreaction to the coronavirus infection.

Called EXO-CD24, the medication is administered directly into the lungs of a patient and regulates inflammation.

Breakthrough Idea

Shiran Shapira, head of the Laboratory of Molecular Biology at the Tel Aviv Sourasky Medical Centre, is one of those who conceived the breakthrough idea.

Shapira says they have administered the drug to 35 patients at the Ichilov hospital where she works. Thirty-four of those who took the medication were released several days after receiving the treatment.

"All of those patients were in severe or critical condition but once they took the drug, their health situation improved and we were able to discharge them within several days".
© REUTERS / AMIR COHENA medical worker prepares to administer a vaccination against the coronavirus disease (COVID-19) at a temporary Clalit Healthcare Maintenance Organization (HMO) centre, at a sports hall in Netivot, Israel February 4, 2021
Israel to the Rescue? New Drug Developed in Tel Aviv Hospital May Help Battle Severe COVID-19 Cases - Sputnik International, 1920, 22.02.2021
A medical worker prepares to administer a vaccination against the coronavirus disease (COVID-19) at a temporary Clalit Healthcare Maintenance Organization (HMO) centre, at a sports hall in Netivot, Israel February 4, 2021

The way it looks now, EXO-CD24 has no side effects and the Israeli media has already reported on a number of happy patients cured by the "miraculous" drug.

But Ichilov is not alone. Israel has a number of other players racing against time to provide the country, and later the world, with a cure for the virus that has already claimed the lives of more than two million people worldwide.

Long Way to Success

Yet what sets Ichilov apart from them all is that their drug has already passed phase one trials and is now set for phase two that will involve dozens of people in Israel and potentially abroad.

Once that stage is completed, phase three trials will be conducted. The latter promises to be a "big study" before maing the medication available to the masses. But Shapira believes advancement from one level to the next will not take long, specifically because there is an urgent need for this medicine.

"It is hard to answer the question when the drug will finally be available for consumption by the general public. We need to wait but I hope it will happen as soon as possible, specifically because there is a rush and a need for this drug, so obtaining a license could become easier and faster".
© Photo Coronaviruses are a group of viruses that have a halo, or crown-like (corona) appearance when viewed under an electron microscope
Israel to the Rescue? New Drug Developed in Tel Aviv Hospital May Help Battle Severe COVID-19 Cases - Sputnik International, 1920, 22.02.2021
Coronaviruses are a group of viruses that have a halo, or crown-like (corona) appearance when viewed under an electron microscope

The pace with which the drug has gone from being just an idea to a developed technology (6 months) gives room for optimism that the medication will soon be available not only in Israel but also in medical centres worldwide.

And Shapira says she's honoured to provide the international community with a potential solution to the problem the world has been dealing with.

"I am very excited [about this prospect]. We have a big team of people, who worked hard to develop this drug and it will be our honour to provide it to the world".
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