"The Zionist regime and its supporters, including the US government, are directly responsible for the dangerous and unpredictable consequences of the continuation of crimes in Gaza as well as the adventuristic attacks on Yemen," the ministry quoted spokesman Nasser Kanaani as saying.
Kanaani condemned Israel's unprecedented airstrikes on the western Yemeni port city of Hudaydah, which killed at least three people and injured more than 80 others on Saturday, saying Israel risked unleashing a wider war in the Middle East.
Iran sees Israel's continuing siege of the Gaza Strip and mass killings of civilians as "the main root-cause" for tensions in the region, the spokesman said, adding that there could be no prospect of peace for the Middle East as long as Israel pressed on with its Gaza offensive.
The Israel Defense Forces said on Saturday that the airstrikes on Yemen were in retaliation for attacks carried out against Israel. Prime Minister Benjamin Netanyahu claimed that the port was being used to ship weapons from Iran. Yemen's Houthis responded by striking the southern Israeli city of Eilat.