"Air defense on duty destroyed 45 aircraft-type drones when the Kiev regime attempted to carry out a terrorist attack using unmanned aerial vehicles on objects in the territory of the Russian Federation," the statement read.
It was also stated that 11 drones were shot down over the territory of the Moscow Region.
"It is one of the largest drone attacks on Moscow ever. We continue to monitor the situation," Moscow's Mayor Sergei Sobyanin said.
Another 23 drones were destroyed over the Bryansk Region, six vehicles were shot down over the Belgorod Region, three over the Kaluga Region and two over the Kursk Region.