According to his Facebook page, the brigade will be trained in line with NATO standards and will only include volunteers, mostly those with combat experience.
He also said that the brigade's chief of staff had studied military science for two years in the United States.
According to Avakov, the creation of the brigade, endorsed by the Ukrainian Commander-in-Chief, should become the first step towards converting the National Guard into a professional army.
More than 7,900 people have already died in the armed conflict in Ukraine that began in mid-April 2014, according to the Office of the UN High Commissioner for Human Rights.
Earlier this week, the Contact Group on Ukrainian Settlement failed to agree on the withdrawal of tanks and other weapons of a caliber of less than 100mm from the line of engagement in Donbass.
The group, which comprises representatives from Ukraine, Russia and the Organization for Security and Cooperation in Europe, was set up in 2014 in a bid to promote a direct dialogue between the conflicting parties.
The extended format of the Contact Group talks includes envoys from self-proclaimed Donetsk and Lugansk People's republics in eastern Ukraine.