The department head arrived in Havana on Tuesday, marking the second official visit by a US administrative authority since the beginning of a new phase of cooperation between the United States and Cuba in July.
Pritzker is expected to co-chair a Regulatory Dialogue with Cuban authorities and hold talks with Cuban Minister of Foreign Trade and Investment Rodrigo Malmierca, Cuban Minister of Foreign Affairs Bruno Rodriguez, and Vice-President of the Council of Ministers Ricardo Cabrisas.
On Tuesday, Pritzker visited the Mariel Special Development Zone to familiarize herself with the area.
In September, the US presidential administration announced relaxed regulations with Cuba, making it easier for US citizens to travel to Cuba and conduct business in the island nation.
Despite the relief in tensions, the United States maintains a trade embargo on Havana mandated by the US Congress.