"It is a hope for Syria in this crisis that we are all meeting here," German Foreign Minister Frank-Walter Steinmeier said prior to the meeting.
On Thursday, the top diplomats from the United States, Russia, Saudi Arabia, and Turkey convened for the first round of talks in Vienna.
Later on Friday, UN envoy for Syria Staffan de Mistura, as well as officials from the United States, Russia, Iran, China, Saudi Arabia, Turkey, Egypt, Qatar, Lebanon and France will discuss the settlement of the Syrian crisis in the Austrian capital.
Syria has been in a state of civil war since 2011, with troops loyal to President Bashar Assad fighting on multiple fronts against opposition factions and extremist groups, including the Islamic State (ISIL).
Since the beginning of the war in Syria, the United States and its allies have supported opposition factions they consider to be "moderate," calling for Assad's resignation. Russia and Iran recognize Assad as the legitimate Syrian authority.