"The expectations are high because this conference probably will raise a lot more money than last years’ conferences," Inas Hamam said.
Hamam estimated total health sector needs to help Syrians in and around the region at $1 billion this year.
"As for the agency, WHO requires $17 million," he added.
According to the UN refugee agency, 13.5 million Syrians are displaced inside the conflict-torn Arab republic, while about 4.6 million people have fled the country, mostly to the neighboring states of Turkey, Lebanon and Jordan.
Germany earmarked $1.3 billion in humanitarian aid this year, the United Kingdom pledged $750 million, and Norway $282 million, among other participants of the conference.
The United Kingdom urged participants to double their contributions to humanitarian aid ahead of the fundraising event to meet the United Nation’s appeal for $7.73 billion.
Downing Street stressed that, last year, only $3.3 billion of the requested $8.4 billion was donated.
The 2016 Supporting Syria and the Region conference is co-hosted in London by the United Kingdom, Germany, Kuwait, Norway and the United Nations. Its stated aim is to raise "significant new funding" for short- and long-term humanitarian support for the Arab republic, which has been ravaged by a nearly five-year civil war.