"Using NATO weapons, the Kiev authorities continue to strike at social facilities, carry out terrorist attacks against peaceful Russian citizens. Our armed forces react as harshly as possible to the actions of Ukrainian militants," Shoigu said at a conference call.
The Western support to Kiev only prolongs the conflict but will not affect the outcome of Moscow’s special military operation, Shoigu said.
"Military support for Ukraine only prolongs the hostilities, but cannot affect the outcome of the special military operation," the minister said.
Shoigu also said that the West supplies more and more military equipment to Ukraine.
“We monitor the amount and routes of supply and, when we detect them, we strike,” Shoigu said.
The defense minister added that Western curators continue to demand from Ukraine to launch mass offensive operations.
"Despite the significant losses of Ukrainian armed forces, Western curators continue to demand that the Kiev regime switch to large-scale offensive operations," Shoigu said.
Ukraine lost more than 16,000 military in May as a result of the military operation, Shoigu said.
"Groups of Russian troops continue to inflict effective fire damage on the enemy. This month alone, its [Ukraine's] losses amounted to over 16,000 military," Shoigu said during a conference call.
Ukraine also lost 16 aircraft, five helicopters, 466 unmanned aerial vehicles, more than 400 tanks and other armored fighting vehicles, 238 field artillery pieces and mortars, the minister added.
Additionally, Russian air defense systems intercepted and destroyed 29 UK Storm Shadow cruise missiles and almost 200 HIMARS long-range guided missiles in May, Shoigu said, adding that Russian troops have recently hit another US Patriot anti-aircraft missile system in Kiev.
The drone attack carried out by Ukraine early on Tuesday targeted civilian facilities of Moscow, minister said.
"This morning, the Kiev regime carried out a terrorist act in the Moscow region. I would like to note that it was against civilian targets. Eight aircraft-type unmanned aerial vehicles were involved in it. All of them were hit," Shoigu said during a conference call.
Ukraine attacked the Russian capital with eight unmanned aerial vehicles early on Tuesday, all drones were shot down, the Russian Defense Ministry said.
Three of these drones were suppressed by means of electronic warfare, lost control and deviated from their intended targets, another five unmanned aerial vehicles were shot down by the Pantsir-S anti-aircraft missile and gun system in the Moscow region, the ministry added.